| Title： | EPG Evidence-Based Clinical Practice Guideline for Diagnosis and Treatment of Familial Mediterranean Fever (FMF) in Children and Adolescents |
| Edition： | Adapted |
| Classification： | Standard guideline |
| Field： | Comprehensive guideline |
| Countries and regions： | Egypt |
| Guidelines users： | Pediatric Immunologists, Pediaric Rheumatologists, General Pediatricians, and Family Physicians. |
| Evidence classification method： | The description of the methodology for the production of this adapted CPG can be fulfilled by utilizing the ‘Adapted ADAPTE’ method. This CPG formal adaptation method included three phases (setup, adaptation, and finalization), nine modules, and 24 steps with modifications in the steps and tools to suit the local general healthcare setting in Egypt. Overall, the steps of CPG adaptation included the selection of the health topic, formulation of the CPG adaptation working group, identification of health questions using the PIPOH model, searching and selecting Source CPGs with clear inclusion and exclusion criteria, quality assessment of included Source CPGs by using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument, assessment of the currency of the selected Source CPG, drafting of the adapted CPG, external review and consultation process, finalization of the adapted CPG with a set of implementation tools, declaration of conflicts of interests, and finally a plan for review and update. For further details on the specific modifications in steps and tools, refer to the article by Amer et al. 2015 https://doi.org/10.1111/jep.12479. |
| Development unit： | Egyptian Pediatric Clinical Practice Guidelines Committee |
| Registration time: | 2022-03-19 |
| Registration number： | IPGRP-2022CN157 |
| Purpose of the guideline: | 1) Provide accurate diagnosis of FMF to avoid over and under-diagnosis. 2) Define the role of investigations in diagnosis and optimizing management and prevention of complications 3) Identify the best practice management of FMF patients. |
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