| Title： | KSUMC Evidenced-Based Clinical Practice Guideline for Management of Severe Sepsis and Septic Shock in Infants and Children |
| Edition： | Updated |
| Classification： | Standard guideline |
| Field： | Comprehensive guideline |
| Countries and regions： | Saudi Arabia |
| Guidelines users： | Physicians Advanced Practice Nurses Nurses Emergency medical technicians/paramedics Clinical Pharmacists Health Care Providers |
| Evidence classification method： | The description of the methodology for the production of this adapted CPG can be fulfilled by utilizing the King Saud University (KSU) Modified ADAPTE method. This CPG formal adaptation method included three phases (setup, adaptation, and finalization), nine modules, and 24 steps with modifications in the steps and tools to suit the local general healthcare setting in Saudi Arabia. Overall, the steps of CPG adaptation included the selection of the health topic, formulation of the CPG adaptation working group, identification of health questions using the PIPOH model, searching and selecting Source CPGs with clear inclusion and exclusion criteria, quality assessment of included Source CPGs by using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument, assessment of the currency of the selected Source CPG, drafting of the adapted CPG, external review and consultation process, finalization of the adapted CPG with a set of implementation tools, declaration of conflicts of interests, and finally a plan for review and update. For further details on the specific modifications in steps and tools, refer to the article by Amer et al. 2019 (https://doi.org/10.1111/jep.12927). |
| Development unit： | King Saud University Medical City (KSUMC) |
| Registration time: | 2022-08-17 |
| Registration number： | PREPARE-2022CN520 |
| Purpose of the guideline: | To provide an update to the First Edition of the adapted CPG for management of severe sepsis/septic shock in infants and children that was issued in May 2010 in PICU, KKUH after reviewing the 2013 update of the source original SSC CPG. To provide evidence-based guidance for the clinician caring for a patient with severe sepsis or septic shock. To emphasize the importance of early goals directed resuscitation e.g. Central Venous Pressure (CVP), Mean Arterial Pressure (MAP), Urine Output, Central Venous Oxygen Saturation and Blood Lactate Level. To specify therapeutic details used in resuscitation and stabilization of an infant/child with severe sepsis and/or septic shock e.g. type, amount and rate of infusion of intravenous fluids, initial investigations, antibiotics, inotropic support and other adjuvant therapies that may be used. To implement these adapted CPG on the national level involving multicenter implementation caring for critically ill septic Pediatric patients. |
Latest registration
