| Title： | KSUMC Evidence-Based Clinical Practice Guideline for Pediatric Hemophagocytic Lymphohistiocytosis (Pedia-HLH) |
| Edition： | Adapted |
| Classification： | Standard guideline |
| Field： | Comprehensive guideline |
| Countries and regions： | Saudi Arabia |
| Guidelines users： | Pediatricians (general, rheumatology, hematology, and critical care) Pharmacists (clinical pharmacists) Nurses (in the previous points of care Healthcare Quality and Safety Professionals Healthcare Facility Administration Health Policymakers Academic Faculty Staff Healthcare Students Patients and Families |
| Evidence classification method： | The description of the methodology for the production of this adapted CPG can be fulfilled by utilizing the King Saud University (KSU) Modified ADAPTE method. This CPG formal adaptation method included three phases (setup, adaptation, and finalization), nine modules, and 24 steps with modifications in the steps and tools to suit the local general healthcare setting in Saudi Arabia. Overall, the steps of CPG adaptation included the selection of the health topic, formulation of the CPG adaptation working group, identification of health questions using the PIPOH model, searching and selecting Source CPGs with clear inclusion and exclusion criteria, quality assessment of included Source CPGs by using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument, assessment of the currency of the selected Source CPG, drafting of the adapted CPG, external review and consultation process, finalization of the adapted CPG with a set of implementation tools, declaration of conflicts of interests, and finally a plan for review and update. For further details on the specific modifications in steps and tools, refer to the article by Amer et al. 2019 (https://doi.org/10.1111/jep.12927). |
| Development unit： | Pediatric Department, College of Medicine, King Saud University and King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia |
| Registration time: | 2022-07-23 |
| Registration number： | PREPARE-2022CN415 |
| Purpose of the guideline: | To adapt evidence-based recommendations for the early diagnosis and treatment of children with HLH. |
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