| 标题： | 骨转移瘤核素治疗专家共识 |
| title： | Consensus of experts on radionuclide therapy of bone metastases |
| 版本： | 原创版 |
| version： | Original |
| 分类： | 专家共识 |
| classification： | Experts consensus |
| 领域： | 诊疗 |
| field： | Diagnosis and Treatment |
| 国家和地区： | 中国 |
| Country and region： | China |
| 指南使用者： | |
| Guide users： | |
| 证据分级方法： | GRADE (Grading of Recommendations, Assess, Development and Evaluation) |
| Evidence grading method： | GRADE (Grading of Recommendations, Assess, Development and Evaluation) |
| 制定单位： | 中国临床肿瘤学会核医学分会；中华医学会核医学分会；浙江省抗癌协会核医学与分子影像专委会 |
| Formulating unit： | Nuclear Medicine Branch of Chinese Clinical Oncology Society；Nuclear Medicine Branch of Chinese Medical Association； Nuclear Medicine and Molecular Imaging Special Committee of Zhejiang Anti-Cancer Association |
| 注册时间： | 2024-04-17 |
| Registration time： | |
| 注册编号： | PREPARE-2024CN538 |
| Registration number： | |
| 指南制订的目的： | 骨转移瘤是恶性肿瘤最常见的并发症之一，尸检表明85%的恶性肿瘤有骨转移，其中前列腺癌、乳腺癌和肺癌等患者的骨转移发生率均可达80%以上。晚期癌症患者的生存时间不断延长，患者出现骨转移及发生骨相关事件（Skeletal-related events,SREs）的风险明显增加，恶性肿瘤发生骨转移后,可导致顽固性骨疼痛、功能障碍、病理性骨折、高钙血症等一系列骨相关事件。特别是广泛性的骨转移、顽固性的骨痛等严重影响患者的预后和生活质量。 骨转移瘤的早期检出对于肿瘤准确的临床分期以及后续治疗策略选择、降低并发症风险和提高生活质量至关重要。随着恶性肿瘤诊断技术的不断改进及治疗水平的不断提高，骨转移的基础与临床研究也得到了长足的发展，特别是骨转移瘤的早期诊断与有效治疗方面。恶性肿瘤转移到骨骼后的综合治疗亦越来越受到人们的重视。目前骨转移瘤常用的治疗方法有外科手术、外照射治疗、放射性核素治疗、激素疗法、化学药物治疗及中药治疗等，各种治疗方法均有其特点和优势。其中利用靶向性的核素内放射治疗是近年来发展较快的治疗方法，它具有疗效较好、方法简便且副作用小等优点，因而该法已成为肿瘤骨转移及所致疼痛的一种新的有效治疗手段。 本共识制定汇集了核医学、骨科、肿瘤内科、麻醉疼痛科、影像科、放射治疗科、精神卫生科等多学科专家，以核素治疗为重点，并突出多学科MDT综合评估与治疗。 |
| Purpose of the guideline： | Bone metastasis is one of the most common complications of malignant tumors. Autopsy shows that 85% of malignant tumors have bone metastasis, and the incidence of bone metastasis in patients with prostate cancer, breast cancer and lung cancer can reach more than 80%. The survival time of patients with advanced cancer continues to prolong, and the risk of bone metastasis and bone-related events (Skeletal-related events,SREs) increases significantly. Bone metastasis of malignant tumor can lead to a series of bone-related events, such as intractable bone pain, dysfunction, pathological fracture, hypercalcemia and so on. In particular, extensive bone metastasis and intractable bone pain seriously affect the prognosis and quality of life of patients. Early detection of bone metastases is very important for accurate clinical staging, selection of follow-up treatment strategies, reducing the risk of complications and improving the quality of life. With the continuous improvement of diagnostic technology and treatment level of malignant tumors, the basic and clinical research of bone metastasis has made great progress, especially in the early diagnosis and effective treatment of bone metastases. People pay more and more attention to the comprehensive treatment of malignant tumor after metastasis to bone. At present, the common treatment methods of bone metastases are surgery, external radiation therapy, radionuclide therapy, hormone therapy, chemical drug therapy and traditional Chinese medicine therapy and so on. Among them, targeted radionuclide radiotherapy is a rapidly developing method in recent years, which has the advantages of good curative effect, simple method and less side effects. therefore, this method has become a new and effective treatment for bone metastasis and pain caused by tumor. This consensus brings together experts from nuclear medicine, orthopaedics, oncology, anaesthesia and pain, imaging, radiotherapy, mental health and other multidisciplinary experts, focusing on radionuclide therapy and highlighting multidisciplinary MDT comprehensive evaluation and treatment. |
最新注册
