| Title： | EVIDENCE-BASED EGYPTIAN CLINICAL PRACTICE GUIDELINES For the Diagnosis, Management and Prevention of Acute Hemolytic Crisis in Infants, Children and Adolescents |
| Edition： | Adapted |
| Classification： | Standard guideline |
| Field： | Comprehensive guideline |
| Countries and regions： | Egypt |
| Guidelines users： | - Primary health care physicians at Ministry of Health (MOH) - General practitioners - Family medicine specialists - Pediatricians - Hematologists - Nurses - Medical students |
| Evidence classification method： | The description of the methodology for the production of this adapted CPG can be fulfilled by utilizing the ‘Adapted ADAPTE’ method. This CPG formal adaptation method includes three phases (setup, adaptation, and finalization), nine modules, and 24 steps with modifications in the steps and tools to suit the local general healthcare setting in Egypt. Overall, the steps of CPG adaptation includes the selection of the high-priority health topic, formulation of the CPG adaptation working group, identification of health questions using the PIPOH model, searching and selecting the source original CPGs with clear inclusion and exclusion criteria, quality assessment of included source CPGs by using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument, assessment of the currency of the selected source CPGs, drafting of the adapted CPG, external review and consultation process, finalization of the adapted CPG with a set of implementation tools, declaration of conflicts of interests, and finally a plan for review and update. For further details on the specific modifications in steps and tools, refer to the article https://doi.org/10.1111/jep.12479]. |
| Development unit： | Egyptian Clinical Practice Guidelines Committee |
| Registration time: | 2022-12-08 |
| Registration number： | PREPARE-2022CN805 |
| Purpose of the guideline: | 1) Putting a differential diagnosis and approach to the etiology of acute hemolytic crisis in infants, children and adolescents 2) Identification of infants, children and adolescents at high risk of developing acute hemolysis. 3) Proper management of acute hemolytic crisis the targeted population 4) Prevention of recurrence of hemolysis in the targeted population |
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